Quoted: Sounds like a solution desperately in search of a problem.
If you really want a big-bore semi-auto with more punch, just load your .45 with +Ps.
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Uh, no
The .50 size offers the ability to construct a hollow point bullet with a cavity that is both very wide and as importantly very DEEP while still keeping solid construction to avoid fragmentation and get proper expansion.
In theory the wide and deep cavity would first of all make the .50 more likely to expand properly in all conditions, regardless of barriers or clothing. The extra mass would make it more likely to reach vital organs while expanding early and reaching a large expanded size.
Now this is only a theory, the cartridge is brand new, still really a wildcat, and needs development. It especally needs a bullet designed for it not shared with the .50AE and .500 S&W that is designed to operate at nearly twice the speed.
It is definently a cartridge that the ammo manufacturers should devote some effort into.
It follows a trend noticeable over the last 5 years or so that the best performing JHP bullets in any caliber are now generally found in the heaviest weights for the caliber. It is simply easier to get better, and more importantly more CONSISTANT, performance from bigger bullets due to the designers having more space and material to play around with.