I'm strongly considering getting one in my 2011 F150. I rarely have a bunch of "big" stuff in the bed, but it would be nice to keep tools and vehicle recovery stuff secure without using a traditional toolbox.
Optimal thing would be to go with a folding tonneau cover over the bed so I could still keep things secure, I'm just not sure how much space would be left between the cover and the top of the decked system for storage.