Yes, Bond's Repertoire of weapons started with the Beretta .25, then to a Walther PPK. In Goldfinger, he used an AR-7.
Bond used a CIA agent's S&W Model 25 in Live and Let Die.
When Sean Connery returned for Never Say Never Again, he used a Suppressed HK VP70. (FYI this is where the Beretta M93R made it's screen debut.)
In Octopussy he used a Walther P5.
In Timothy Dalton's debut as Bond, he used a PPK and took a shot with the ever-so-sexy Walther WA2000 Sniper rifle.
When Pierce Brosnan took the wheel in Tomorrow Never Dies he picked up a Walther P99.
The P99 (with Suppressor) reprised it's role with Bond in the World Is Not Enough along with a notable use of a box-stock M1911s (In the opening sequence and in the final showdown with the villaness, played by the Delectable Sophie Marceau).