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Posted: 10/24/2004 10:46:32 AM EST
I recently had a checkup to see how my cholesterol medicine was working, 10mg of Crestor daily. My results were:

ldl 75
hdl 45
tryglicerides 126

That all seems great, but they said my liver function test was 50, and it should be 40. They asked if I drank or took tylenol. I haven't had a drink in years, and rarely use tylenol. I do take Celebrex daily though and have so for around 4 years.

I'm 34, 147 lbs, 5'6", get little to no excersize, and have a family history of heart disease. I smoke, but do not inhale, cigars.

What's the deal on the liver test? Should I be worried?

Balming
Link Posted: 10/24/2004 10:48:15 AM EST
didn't they just declare Celebrex a fucked up drug? Or is that another medication i'm thinking of?
Link Posted: 10/24/2004 10:50:13 AM EST
That was Vioxx, a very similar drug.
Link Posted: 10/24/2004 10:50:34 AM EST

Originally Posted By lokt:
didn't they just declare Celebrex a fucked up drug? Or is that another medication i'm thinking of?




You're thinking Viox, and Celebrex is next on the list.


SGtar15
Link Posted: 10/24/2004 10:52:24 AM EST
nothing some fava beans and a nice chianti wont fix!

thbthbthbthbthb!!!!!!
Link Posted: 10/24/2004 10:52:38 AM EST

Originally Posted By Balming:
I recently had a checkup to see how my cholesterol medicine was working, 10mg of Crestor daily. My results were:

ldl 75
hdl 45
tryglicerides 126

That all seems great, but they said my liver function test was 50, and it should be 40. They asked if I drank or took tylenol. I haven't had a drink in years, and rarely use tylenol. I do take Celebrex daily though and have so for around 4 years.

I'm 34, 147 lbs, 5'6", get little to no excersize, and have a family history of heart disease. I smoke, but do not inhale, cigars.

What's the deal on the liver test? Should I be worried?

Balming

SAME thing happened here... I was chewing my nails worrying about it and after test after test and needless worrying, found out that 3 of my friends had the same thing... just cut down on fatty foods and excercise more. No biggie
Link Posted: 10/24/2004 10:55:31 AM EST
Link Posted: 10/24/2004 10:57:32 AM EST
Why is it that when I hear of human livers...I think of fava beans?
Link Posted: 10/24/2004 10:59:23 AM EST
[Last Edit: 10/24/2004 11:01:34 AM EST by DrFrige]

Originally Posted By Zippy_The_Wonderdog:
Why is it that when I hear of human livers...I think of fava beans?



Oh simple... because you are a sick individual who has deep seeded thoughts of mass killing and hiding the bodies under the house with dreams and aspirations of opening up a FIRST human parts butcher shop catering to those that have the same sick ideas as you...

Thats all.

ETA: Honestly if it is just the liver and fava beans, I wouldnt worry... now if you start thinking human kidney with onions and human tounge with broccoli and mustard... Theeeeeeeeeen we have another issue.

"Emeril Zippy"..... I can see it now.
Link Posted: 10/24/2004 11:05:27 AM EST
you should really be taking milk thistle extract to protect your liver when you are on drugs that are proven to be harsh to your liver.

you only get one, so you should protect it.

i recommend a product called thistlyn.
Link Posted: 10/24/2004 11:10:22 AM EST
Link Posted: 10/24/2004 1:32:58 PM EST
[Last Edit: 10/24/2004 1:33:44 PM EST by rkbar15]
What does your doctor say about your abnormal liver function test? Quit smoking and get SOME exercise!

CONTRAINDICATIONS

CRE­STOR is contraindicated in patients with a known hypersensitivity to any component of
this product.

Rosuvastatin is contraindicated in patients with active liver disease or with unexplained
persistent elevations of serum transaminases (see WARNINGS, Liver Enzymes).



WARNINGS

Liver Enzymes
HMG-CoA reductase inhibitors, like some other lipid-lowering therapies, have been
associated with biochemical abnormalities of liver function. The incidence of persistent
elevations (>3 times the upper limit of normal [ULN] occurring on 2 or more consecutive
occasions) in serum transaminases in fixed dose studies was 0.4, 0, 0, and 0.1% in patients
who received rosuvastatin 5, 10, 20, and 40 mg, respectively. In most cases, the elevations
were transient and resolved or improved on continued therapy or after a brief interruption in
therapy. There were two cases of jaundice, for which a relationship to rosuvastatin therapy
could not be determined, which resolved after discontinuation of therapy. There were no cases
of liver failure or irreversible liver disease in these trials.

It is recommended that liver function tests be performed before and at 12 weeks
following both the initiation of therapy and any elevation of dose, and periodically (e.g.,
semiannually) thereafter. Liver enzyme changes generally occur in the first 3 months of
treatment with rosuvastatin. Patients who develop increased transaminase levels should be
monitored until the abnormalities have resolved. Should an increase in ALT or AST of
>3 times ULN persist, reduction of dose or withdrawal of rosuvastatin is recommended.

Rosuvastatin should be used with caution in patients who consume substantial quantities of
alcohol and/or have a history of liver disease (see CLINICAL PHARMACOLOGY, Special
Populations, Hepatic Insufficiency). Active liver disease or unexplained persistent
transaminase elevations are contraindications to the use of rosuvastatin (see
CONTRAINDICATIONS).
Link Posted: 10/24/2004 1:40:27 PM EST
[Last Edit: 10/24/2004 1:42:09 PM EST by The_Beer_Slayer]
Link Posted: 10/24/2004 1:42:14 PM EST

Originally Posted By sgtar15:

Originally Posted By lokt:
didn't they just declare Celebrex a fucked up drug? Or is that another medication i'm thinking of?




You're thinking Viox, and Celebrex is next on the list.


SGtar15



Get a lawyer...I know of a good trial lawyer from North Carolina who'll be looking for work come November 3rd...
Link Posted: 10/24/2004 1:52:48 PM EST
Just follow it.
Did they do LFTs prior to you starting the Crestor?
The Crestor can definitely raise your liver enzymes but this is minimal so far and not much reason for concern.
Link Posted: 10/24/2004 2:57:52 PM EST
Phamacy tech wife says" the drug ...watch for your future tests or ...How about genetic history?"

GL man
Link Posted: 10/24/2004 4:56:26 PM EST
Steady, what are you saying?


Balming
Link Posted: 10/24/2004 5:01:57 PM EST
Exactly why I will never take any cholestorol drugs.
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