Check with the airline(s). Some of them have classes, or they might have a video or web page devoted to these issues.
I've flown plenty.
Expect changes in noise, cabin air, lighting (even a flicker or two) and inertia.
There will always be a little anxiety at takeoff (there will probably be a slight sinking illusion at liftoff, followed by hydraulic noise and thunking sounds as they retract the landing gear).
Ditto for landing. Changes in engine noise and decceleration as they intentionally drop altitude, extend flaps, and make unannounced turns - they just don't have time to explain everything they are going to do. More noise extending the gear. Touchdown may be smooth or a bit clunky, and as soon as the nosewheel is down, they will activate thrust reversers which use engine power to brake the aircraft, followed by the disc brakes.
All this stuff is entirely normal and happens with hundreds of thousands of passengers every single day.
Your biggest chance of a problem on your trip will be the drives to and from the airport especially if you're all medicated. Or losing your temper at the poorly-educated non-citizen security people.
Try to keep your mind on your carry-on stuff as you go through security. Very easy to get distracted while they're feeling you up, meanwhile somebody picks up your laptop, backpack, whatever. Or you forget and leave it there on the conveyor.
Oh yeah, don't make any nervous jokes about drunk pilots or bombs or hijackers.
There is always a chance of a bumpy ride in spots, often they can tell you what to expect with this, because they can see conditions on radar. Keep the seat belt on and take some bottled water. Air travel dehydrates you due to the dry, poorly refreshed cabin air. Also it's my belief that this causes increased chances of viral infections, so get plenty of sleep and take care of your health in advance.
Oh yeah, check ahead of time re your carry status if you intend to, regardless of any special consideration you may have.