It really is kind of impossible to determine (from the pic) where it all exists. It looks as if it is in program files, which is the original installation of the program.
Then there is an instance of it in documents and settings which may or may not need to be there, depending on where it is.
Then you have an instance of it right on the C drive.
Maybe the best thing to do is uninstall (backup anything that needs to be, I dont know what the program is all about) and reinstall to the folder program files.
Basically, if you installed the program multiple times and changed the path to where it was installed during the installations, then you have multiple copies of the program on your system.
More than likely, though, those files are needed to be there to run the program