I played around with w 748 all summer long using Nosler 50 gain BTs, 52 grain match, 55 grain Varmageddon, and Hornady 55 grain FMJBT. In the summer heat, I was running 27.1 to 27.5 on the 50/52s and 26.6 to 27 on the 55s. This was with R-P and FC brass with #41 primers. The only problems with excessively flattened primers were encountered with the 55 grain Varmageddon due to the flat base. I could get at a minimum 12 reloads with annealing every other reload. The 50 grain BTs shot a no shit 1.5 inch 5 shot group at 300 yards. At 100, my eight year old daughter could shoot 5 shot 1/2 inch groups.
Just yesterday, I loaded up some of the 52 grain match with 28.5 and 29 grains. Even with the cooler weather, there were flat primers, but no ejected primers. They chronographed at 3350 and 3410, respectively. This is out of a 24 inch barrel. Not a chance I would try that in August. The brass really took a beating.
Compared to other powders that I have used, 748 seems to be pretty mellow. H322 or the old 8208 surplus burns way quicker, while the 748 is kind of like whoosh, like idling down the freeway. Nothing too scary about it.
Also, pay attention to the bearing surface of the bullets you are using. This affects pressures big time. Chamber dimensions affect it also. I am using 5.56 chambers.