I've heard accuracy on these is poor in comparison to FMJ projectiles.  I usually use 115 GR FMJ for target and comp.  I would like to use these 122 grain lead truncated cone semi wad cutter due to the availability but, I don't want to lose accuracy.  Any input or feedback?  If they are acceptable, 3.5 to 4.5 grains Tite group or 231 seems to be an applicable powder charge.  Any suggestions or disagreements here?  Thanks for your time, its much appreciated.

It depends on the details. What are the details?

They will be used for league and competition shoots.  Projectiles made from virgin lead alloy 92% lead, 6% antimony, 2% lead. Triple lubed, sized .356".   I will reload using once fired, fully processed Winchester brass and small primers on a single stage press.  I will use the listed powders: Titegroup or 231, maybe bullseye powder.  Fired from my Ruger p-89.  Any details I left out?

Stand bye...

The December-January issue of Handloader Magazine talks about your bullet, albeit a bit heavier @ 125grs, over 4.2 grains of 231 @ 1.075" OAL in FC cases and FC primers delivering 1" groups at 25 yards from a S&W 952-2.