It seems like 6.8, 6.5G, .50B, 458S at least are fairly well established and are growing in popularity and scope of production every day. 6.8 has the benefit of being backed by major ammo manufacturers, but the others getting more press time with bigger and bigger companies. I don't think they will die. Not sure on the .450Bushy yet, as it is so new. It was released by Bushy though, so that is a bonus for them, plus Hornady is making the ammo. They have a jump on the others from when they were in their infancy. It started with major backing. We have seen some calibers go kaput too, like the .499LW (yes, everyone will say it is in redevelopment, but it is not out there right now and will be basically a new caliber if it ever comes out again), and others I am sure. Seems like most do ok if they get some backing, even if it is small manufacturers. The 6mmAR looks like a great caliber which is a 6.5G necked down to 6mm, but not sure it will get a strong market share, or the 7.62x40 or other "wildcats" that are probably great calibers, but may remain a niche market.