Most of what is cut away from the 6 lug is from the front side, the one closest to the round. If you compare the back side to the rifle cut, you see that there is little or none taken away from the area, and this is where the bolt will lock up anyway. If there is any weakening, and I doubt there is, it is to be so negligable as to not be worth talking about. There is so much real estate taken up by the other lugs that I doubt you would even miss the sixth, were it not even there.
I have one AR with M4 cuts. It makes not a shit of difference for me shooting semi-auto all day long between the rifle ramps and the M4. With full auto, I guess it makes a difference, but not for what you and I are going to do with the weapon. All my AR's shoot the same, M4 or no M4 cuts, I personally think it would be easier to go back to the rifle cuts to make it easier to mate with the vast preponderance of barrels out there, without having to monkey around with making a rifle extension work with an upper with the M4 ramps. Pain in the ass for me.
That's just my .02. YMMV.