If .264 / 6.5mm was my home defense caliber, I would like to see a 95 gr VMax or 85 gr Sierra HP Varmint. Explosive expansion, with minimal penetration through multiple walls.
Having said that, the only
factory 6.5 Grendel round that makes sense to me is the Hornady 123 gr. Amax or SST.
I specify factory, because I would personally never use a hand loaded round for Home/Personal Defense. While some may disagree, (and they're welcome to do so), a common CCW school of thought is that using hand loads is just begging for trouble. Reliability issues aside, you could be exposing yourself to a whole different level of legal concerns. In the event of a defensive shooting (even if perfectly justified and immaculately performed), any half-baked attorney could easily paint a picture for a jury. He would describe you sitting at your reloading press, fantasizing about the body count each time you pull the lever. In today's schizophrenic gun culture there is no telling what a jury pool might look like, and I say that the fewer troublesome facts involved, the better.