I went "barefoot" for footwear about a decade ago and finished my military career shifting to running with barefoot shoes and wearing the Mini-Mil zero-degree boots. They've made a significant impact on improving my arches, strengthening my ankle and knee joints. I'm a believer.
One caution on such footwear for backpacking is to understand the difference between cushion and zero-degree. I've tried a couple times to hike in barefoot shoes and it turned into a disaster. The feel is great on the trail for the first few hours, but what I found is that my feet took a pounding and were extremely fatigued. Maybe not enough practice, but I had been running, working out and did numerous day hikes with barefoot shoes. Doing 8-10 hours on the trail with a pack for a few days is another story. I still use barefoot shoes for day hikes, but went back to Salomon shoes for backpacking as they have much more cushion.
On the plus side though. While my feet were extremely sore and fatigued, they recovered very well overnight and I would be fine for the first few hours the next day. Another aspect is that barefoot shoes slow you down, which is good and bad. It forces you to really pay attention to where and how you step, but it slows you down quite a bit (not the best feature when doing a distance hike).
I've love my Belleville Mini-Mils, Vivobarefoot, Xero Shoes, Inov-8, are some of my favorite choices...
ROCK6