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The difference in barrel length probably dictates the difference in velocity and expansion. If you're around 2200, I'd say you're ok.
Serious question, does "overpenetration" really matter in hunting applications? Personally I don't think it does, so I would ignore that part of the discussion.
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Yes and no, depends on who you talk to
Some prefer the bullet to stay in the animal, 'dumping' all of the energy. Others prefer pass through ("over-penetration") as generally an exit wound produces a better blood trail. Passing through also tells you it didn't get stopped/deflected by bone, or at least not completely.
On smaller, more fragile animals, a bullet that quickly expands will likely do so closer to the vitals. A bullet that doesn't expand for 6-8"+ may be in the animal far enough before the expansion can really do its job. That's why for small varmint, 'exploding' bullets are preferred because they literally act like a grenade on impact. Some of the tougher bullets are designed to punch a bit before expanding, capable of moving into tougher hides, break bone, etc