Sometimes thing were simpler when I didn't have a golf bag of arms to choose from. Way back when I carried a Nylon 66 on the outside of my pack, muzzle down, in the side pocket tunnel, pack lid covering the butt, when I was hiking the White Mountains and all around Maine. I'm not even sure most people who saw me knew what it was.... this was back in the 1980's to early 90's. It was, and is, a perfectly satisfactory survival piece. Light, reliable, accurate enough.
These days it's unlikely that I will ever be forced to choose just one, two, or three guns...but if I did it's because I am bugging out from or to somewhere on foot.
For that I'd use a .22 pistol (no suppressors here but that would be ideal) for small game and quiet stuff, the lightest AR I had with a red dot and magnifier, removable light, and a decent sling. Maybe a pistol version. And a compact handgun, concealed. If I was abandoning all of my other stuff it would be in a really bad situation and my concerns would be security/self defense first, foraging for food second (hence the .22 pistol). But weight would be a consideration. I'm not he 22 year old infantryman I once was and humping 100 pounds of food, ammo, gear isn't something I'm capable of any longer.
If I had to select one home defense rifle, one survival rifle it'd be a good AR and a 10/22. I can't do iron sights very well any longer (I'm getting old LOL) and I've become enamored with small red dots and magnifiers. My fave is a Holosun with the ACSS reticle, which shines with 3 or 6 power magnification. For long long "holy crap 'the Road' was an optimistic movie" stuff I do have an ACOG set aside. 10/22 is in the factory synthetic stock and has a 4x scope on it. It's light and a fun little rifle.
I'm not sure if that's of any use.
If it's the "one rifle for life, the apocalypse, and everything" that's different.....