A 5 db. loss on 160 through 20 meters won't be as noticeable on the RX side, as on 10 meters or worse - VHF/UHF frequencies. You may be able to compensate the TX losses with an amplifier. Yes, it's not optimal but you will be able to enjoy most HF bands.
Obviously, like others mentioned, an open air balanced transmission line is a good choice to long runs on HF bands. If it's not practical, buy some hardline, if you can afford it. Buy once, cry once.
You know, back in my early days, low loss coax was unobtanium. I ran about 250' of crappy, lossy 75 Ohm TV reception cable. I never measured the losses but I worked several hundred DX entities with a home made transceiver, single output tube with about 40-50 watts output. It worked just fine. The antennas were on top of a 5 story apartment building. Balanced transmission lines were impractical.
Also, try to get the best antennas you can afford. This hobby is all about antennas if you really want to really enjoy it.