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UPDATE:
I recently picked up at Ruger American standard in 243 Win. I've read good things about 243 as a whitetail caliber. It was not my first choice, or even my second, but I found them on sale online for $279. With a $20 coupon I got it shipped for $269. I couldn't pass that up.
Now I just need to find a 3-9x to put on top.
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.243 is in that range where there are these light, super fast bullets that like to come apart upon impact....they also don't like bones. I've been on more than a few VERY long tracks with 243 wounds. One was a very solid, what should have been a double lung, hit on a 3.5 year old Wisconsin buck, we eventually found him with a dog. The bullet fragmented almost immediately upon entering with a direct hit to a rib. Nothing made it to the off side lung. Made an absolute mess out of the on side lung though. I don't remember the bullet weight, but this was a factory Hornady SST round. Shot was broadside at about 70 yards. Remington 700.
Guy is a good hunter and a good shot, I shoot with him often and he said the shot felt very good so we were comfortable tracking after a half hour considering he didn't see the deer fall. 300ish yards later we jumped the first time, no shot. Another 300ish over a ridge we jumped him the second time, again no shot. Quite confused at that point we convinced ourselves that he didn't hit the deer well and we backed out till morning(assumed single lung/liver/gut shot even though the trail didn't look like liver/gut at all). Rained overnight, so we called a friend with a dog. Deer circled back to it's first bed area and died in it's bed but was still warm in the arm pits. So it lived a while after we backed out.
I've now been on/heard of probably 8-10 long tracks of deer shot with .243 in the last several years. If they find them, it's usually that story bullet fragmented upon impact and doesn't penetrate far enough to put the deer down quickly.
Basically, moral of the story is, make sure you use the correct bullet with enough weight and construction to penetrate effectively. Especially on close shots.