I-74 isn't complete, it is just in sections. It's eastern portion mirrors US-74. There is basically nothing east of Charlotte on US-74 until you get to Wilmington. The western portion comes off I-77 at Mount Airy, and I believe follows US-220 south to maybe Hamlet?
Of the areas I can think of, Hillsville/Fancy Gap VA would be the most scenic, nice places to stop in that area. That's FIRM Virginia Tech Hokie territory; Frank Beamer is from Fancy Gap. Be careful in that area on I-77, there are some nasty wrecks through there because of fog.
Wytheville, VA wouldn't be terrible, but it may not be far enough into the trip. It's at the junction of I-81 and I-77.
Between Wytheville and Hillsville on the New River you'll see the Shot Tower, which is in a Virginia State Park. It's right off I-77 and would be an easy historical pit stop. It was an ammunition factory, where they dropped molten lead from the top of the tower into the river below, and the method made perfectly round musket balls.
Winston-Salem, NC probably has some decent places, it'll be the last "main" city on that route. The route is really weird, in that it doesn't go through any big cities at all. It cuts through the middle of nowhere. And it'll be a good 5 hours from WS to Wilmington, maybe more.