I only have a sample size of one, but I was not impressed with the performance of my 300BO with a 110gr VMax on a 50 yard broadside shot of a small/medium sized buck this year. If I use it again, It'll definitely be with a different bullet. But even with a different bullet, I'd limit myself to 100 to 125 yards. This year, it was sort of a last minute decision to use the 300 vs 12ga, and the 110gr VMax was the only ammo I had available. I did a fair amount of internet research that suggested that the 110 VMax at 300BO velocities acts more like a soft point bullet vs a varmint bullet. It held together fine, but deflected off a rib and penetrated rearward into the deer and failed to hit the heart and opposite side lung (which was what I was hoping for), with no exit wound. Despite it resulting in a kill after an 80 yard run, it left zero blood trail to follow. Thankfully, I saw the direction the deer ran and was able to recover it within about an hour of searching.
That said, I definitely would not use the 300BO for a 180yd shot. I think the 308 in pistol configuration would service you well with proper bullet selection and shot placement at that distance.