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Judging from the lack of replies, I'm going to guess not many people are using a RDS on the M&P22 pistol.
I did find a company called EGW that makes a plate that will fit the M&P22. Even their site specifically says using their plate and a RDS could add enough weight to the slide that will cause cycling issues.
I have emailed Smith and Wesson to see if this is something they have done or would even recommend doing. I will make a follow-up post when I get an answer from S&W.
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You didn't specify M&P22 full size or Compact, but I'm running a Burris FF3 on my M&P22 Compact (using one of the EGW mounts) with no problems.
Pay no attention to the giant rubber protector.
I run mostly CCI MiniMags through it without issue.
I'd like to find a mount for the Holosun 407K, which I think would be even better, size-wise.