For hand size reference, XL gloves are generally snug, and XXL gloves are a little loose.
I used to own an HK45 v1 LE and P2000 v3 LE chambered in 9x19, and stupidly sold both. The HK45 is pretty tall. With my hand as high up on the frame as possible, there is still a small amount of frame sticking out under my hand, as well as the large magazine base pad.
I just got home from picking up a brand new HK45c v7 LE. This frame seems identical to the P2000 frame. I tried to use flat low profile base pads on the P2000 and I found that my accuracy suffered because my pinky finger would hang off the frame. With the normal "extended" rubber base pads, my pinky finger had something to grab onto and my accuracy was way better. This new HK45c is the exact same way. Without the magazine inserted, my pinky finger hangs off the frame. With the magazine with normal "extended" rubber base pads installed, my grip feels much more secure.
People compare the HK45c to the Glock 19, but honestly I think the frame is shorter on the HK45c than the G19. I can get a full grip on a G19. It's tight, but my pinky finger is secure. With the HK45c/P2000 with low profile base pads, my pinky definitely sticks off the bottom of the frame.