.380 is a hard little beast to find good ammo for. For the most part, they either expand well and don't penetrate adequately, or the penetrate well and don't expand adequately. There just isn't enough energy there to do both, like you can get in 9mm, .40 and .45.
If you subscribe to the FBI methodology for picking ammo, there are a few loads that will both penetrate reasonably well in .380 (at least 12" in organic gel, no more than 18") and expand much at all. Even those that can expand, do so very modestly, nowhere near the .6"+ sizes that you can get out of regular service calibers. Of those that meet these guidelines, the best seem to be any of the various loads using Hornady's XTP bullet. Fed Hydra Shoks are a close second, but they don't seem to expand well at all and, when they do expand, they usually expand unevenly. They do, however, usually stop before penetrating 18", which reduces risks of overpenetration. Gold Dots also seem to work well, but usually stop just short of 12". The XTP loads can usually penetrate at least 12" (not much more, but they do seem to reliably exceed 12") and they do expand some (not large, IIRC about .4-.45", but they do also reliably expand) and seem to do so even with through clothing. There are some expressing concerns about results in Clear Gel, concerns that the gel may not work as reliably and as repeatably as regular organic gel. As an example, in Shooting The Bull's testing, HSTs don't penetrate well (again, IIRC, only 9-10" or so) but they do expand very well. STB started out using Clear Gel for some testing but stopped using it because he was having issues, and only used regular organic gel for later testing, including his HST testing. In contrast, Lucky Gunner uses Clear Gel exclusively, and some of their testing differs from testing done in organic gel. This is one of those times when "you pays your money and you takes your chance". Myself, because of a lot of research, I tend to believe repeatable results in organic gel over Clear Gel.
If you are interested in some of the "exotic" loads, like the Lehigh Xtreme Defense or Xtreme Penetrator, I'd be very careful with them. I'll preface my remarks by saying that I WANT them to work. However, I don't think they will, and I'll tell you why. Because of my work (I'm the rangemaster for the PD I work for and get to make all the decisions about guns and ammo), I have taken some classes about terminal ballistics, as well as doing my own research out of interest in the subject. Without going too deep into the weeds, at pistol velocities (less than about 2200 FPS), human tissues do not rip and tear, they just get kinda pushed out of the way, then snap back into place because you haven't exceeded the elastic limits of the human tissue. All pistol bullets do is poke a hole and the bullet cant destroy any tissue that it doesn't touch. Both organic gel and Clear Gel are more rigid than human tissues, and the only results they are supposed to show reliably are approximate penetration and approximate expansion. That is all, just approximate penetration and approximate expansion. All the damage you see along the wound tracks in gel just don't equate to human tissues because the gel is more rigid and not as elastic as human tissues. As a result, I'm extremely skeptical about the claims made about the Xtreme bullets. Because they don't exceed 2200 FPS, logically all they should do is push tissue out of the way and only work about as well as standard FMJ bullets. Without exceeding 2200 FPS, I can't see these bullets doing what the manufacturers say they will do. Like I said, I hope I'm wrong and they work, but until we get actual shooting results, I won't hold my breath.
Bottom line, my advice is to pick any of the loads using Hornady's XTP bullet and, as long as they will feed in your gun, you should be OK. Good luck with your decision.
Bub75