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I wouldn't be all that concerned about mold. I think it's overblown.
Like before mold was discovered how did people keep their houses cool?
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You mean before mechanical refrigeration gave us the ability to mitigate mold?
People dealt with it as a normal part of life, just like scurvy, diseases, etc. People died younger too. Ignorance is ignorance, until you learn better, then continuing that is just willful ignorance. People simply didn't know better but once they did they changed their habits, at least the smart ones did.
Just because people USED to tolerate things that could harm them and damage their homes doesn't mean we shouldn't try to mitigate them to lead a more healthy life, or better protect our homes from the elements. That argument is asinine.
Homes were also built differently then too.
You also must keep in mind that opening an entire home up to natural ventilation (what would have been done in that time period) doesn't create such extreme temperature and humidity differentials. Selective ventilation like OP is describing will create moisture condensation, especially in the midwest.