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I'll be running two to four people daily. The bed will have a hard tonneau cover for the equipment. Nothing super heavy just expensive and will need to be secure. The off-roading will be dirt trails, dirts roads and farm land.
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Have you considered a Tahoe or Suburban? Security should be better than a truck with a tonneau cover.
4 adults means you're going to want a crew cab with 4 legitimate doors and a real back seat. Sounds like a 1/2 ton is what you're looking for based on the payload requirement.
In the last year I've rented MY 2018 Dodge, GM & Ford 4wd 1/2 ton trucks for 1 week each and logged 500-1500 miles in each of them. I'm 6'4" and I found all 3 to be comfortable and easy to drive. I've also rented a loaded 2018 Suburban and put ~500 miles on it - pretty nice ride IMO.
I don't think you could go wrong with any of the "Big 3" brands.
Try checking with some of the big corporate employers in your area that have fleet/pool cars to see if you can get one before they turn it on the lease or go directly to Element Fleet Management to see if you can buy directly from them.