I have a 762mini2 that I've owned for over 2 years now. It is my only rifle can. Mine has seen use on 5.56 AR, .300blk AR, and .308 bolt action guns.
I have no experience with the RC2, but I have spent time behind an original RC. Anecdotally, the 762mini2 sounds significantly quieter behind the gun than it's 5.56-bored sibling (the RC w/ 16" barrel vs the 762mini2 w/ 14.5" barrel, both mid-length fixed gas). ETA: the at-ear 5.56 AR signature gap between these two silencers 1. can obviously be a characteristic shared by other .223/.30 caliber silencers of identical form factor/design and 2. likely becomes much less significant as barrel length shortens. OP, if you're shopping for a silencer to be primarily used on 5.56 guns and you're decided on Surefire it then becomes a simple decision of ear/muzzle performance prioritization and use case. My acceptable performance threshold for 5.56 is pretty low so I chose to prioritize flexibility of use on a higher number of calibers/hosts.
I have no experience shooting .300blk through any can other than the 762mini2. In spite of that, I believe it achieves good supersonic and adequate subsonic performance.
I see no need to speak to the 762mini2's performance on .308 after Pew science's timely data release today. For its high rate of gas flow and handy form factor, I do think this suppressor would shine on a .308 autoloading gun.
10/10 would buy again. I will be getting another rifle can with HUB threading. Whether it will have a .223 or .30 bore I've yet to decide, but likely will be another .30 cal.