Lets walk this through step by step.
First we need to enlarge the bolt face recess, and rework the extractor and ejector for a case that will have a rim .572" (stated at .473).
Next, we have to re-chamber a heavy barrel from it ID of .470 in 06, to .513" at the back of case/.532" at the belt.
And to point out, would need to do such on a heaver full contort barrel, and not the standard barrel.
http://www.bearblain.com/images/Barrel%20Full%20Contour.png
As for barrel thread section at the receiver, that is not going to change, so all the enlarging we did to the bolt face and barrel chamber ID size, just produced weaker parts a the receiver barrel threaded section.
As for feeding the beast, 300 win rounds are not going to fit correctly in Garland clips, so this means at BM-59 type mag conversion on the receiver, and bases on BM-59 300win mag as well.
As for working pressures we go from the 30-06 of having a max at 60K, while 300win mag at 64K isntead; and again on parts that we just weakened, and on a receiver that was only designed for 60K max to begin with. Also, very easy to bend a Garand opt rod, so even another tune off, even if the gas port was sized correctly as well.
So if all of this alone has not turned you off on the project, then not sure your seeing the big picture here to start with.
So it really boiling down if you could, verses if you should, and the answer is no, since ever if you did, the rifle would have a very short live before parts did start to fail quickly instead.
Hell, smith'g time, would only take about 4 Hrs to do the needed mods, but no smith in their right mind is going to do the work, since when the rifle does start to crack parts and puts the users life in jeopardy, it will be their insurance/livelihood on the line instead.