Dusting off physics neurons that haven't been used in 35 years, different altitudes will have a negligible effect on muzzle velocity.
In the case of 45ACP, you have 21,000 PSI at the most on one side of the bullet and anywhere from 26 to 29 psi on the other side. 3 pounds of difference is only 0.014%. 9mm would be .009% and 223 Rem .005%. That would be very hard, if not impossible, to see on any consumer crony in 3 shots.
With that said, air pressure after the bullet leaves the muzzle has a much larger impact on the bullet's deceleration, so the higher the real ambient pressure the quicker the bullet loses velocity. The effect is more pronounced the faster the bullet is traveling. Rifle bullets at 3000fps will slow down much faster than pistol bullets at 850fps.
With power factor being measured 5 feet from the muzzle, I'd be really surprised if you could detect any variation without 100s of shots being fired. Your standard deviation in velocities will most likely swamp any differences in deceleration caused by more or less air pressure at that range.
The difference in rifle bullet drop at 1000 yards might be measured in feet at different density altitudes and at that range, air pressure is a big deal. Retained energy and current bullet velocity will also take a big hit. The trajectories will be completely different past a few hundred yards.
But my understanding of your question was pistol power factor for an USPSA match and I don't think you could tell the difference at different altitudes. ***edit: But if it makes you feel better add 0.1gr to your load.