@jle57, you have a good question and one I am dealing with as I am getting into the MPX and MCX platforms.
One of the main selling points is the modularity and end user customization of the gun for certain uses and setups. Quick change hand guards, barrels and stocks/braces is one of the draws of the platform for most of us.
However, as others have said, it is a bit of a pain to have to swap barrels in and out and re-zero (or trust your old zero) for optics. I have read corregon state the re-zero of handguard was fixed in the current MCX and does return to zero. Barrel supposedly has good return to zero as well, but have also heard some guys state it doesn't.
So I guess you could have certain optics zero'd for certain barrel calibers and lengths. I would recommend you should still check your zero. Use of multiple barrels does get the most out of the platform in terms of the modularity design of it.
Or, having multiple complete MCXs does make life a lot easier; grab and go. Especially if you plan to use the certain setups often. If you are only going to have 1-2 setups that you will use the vast majority of time, and then have extra barrels as backups or for setups you won't use as much, I can see benefit of swapping barrels in and out. Really just depends how you want to use the MCX platform. There isn't a right or wrong way in that regard. Just depends on what you want out of it, your budget, how much room you have in your safe...etc.