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For me .300blk without a can doesn't offer enough of an advantage to offset the price of ammo. Where it shines is short range, short barrels, subs, and a can.
556 M193 is cheap and offers a lot for the price if you can keep it around frag velocities.
If were talking about more expensive rounds then I would rather have a 62gr bonded soft point for defense like the Speer GDSP or Fusion/MSR. Those bullets will expand down to 1800 FPS. Which extends your range and keeps your bullet doing whats its supposed to do at further ranges.
If were shooting at extended ranges then that's when I would look more towards the 77gr stuff.
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Here is the issue. For M193 to do it's thing, it needs to be above 2700 fps. By 2500 fps, there is no fragmentation. Since we are talking short barrels, this really isn't the best area for M193. So we move on to more expensive ammo no matter what.
Plus 5.56 is really loud and blasty out of short barrels.
For expanding rounds:
I'll take 110gr .308 Tac-tx over 50gr/62gr/64gr .224 rounds. Tac-tx for .300blk expands down to 1300 fps (factory listed). Out of a 9" barrel, that is +350 yards.
For fragmenting rounds:
I'll take 110gr .308 Vmax over 75gr/77gr .224 rounds out of short barrels. Vmax for .300blk is "supposed" to fragment down 1600 fps (factory listed), although I would add quite a bit of cushion to that. (Out of a 9" barrel, 1700 fps is 190 yards. 1800 fps is 150 yards).
But all of that is subject to purpose and barrel length.
My 12.5" 5.56 is a good barrel length, it just gets squeezed from both sides. At really short ranges, I'm not getting much of a benefit out of 3.5 more inches of barrel over my 9" 300blk. And once you get into that 12.5" barrel length range, there are a lot of other small frame calibers that start to make sense as well (6.5, 6.5, 300Ham'r, etc). It's probably why my 12.5" spends a lot of time what that 22LR bolt it in it.