Think about your AR pistol/ PCC/AR15 that's going to be used in an urban environment. If you're right handed, ideally, you'll want to use the right side of your cover. But sometimes, you have to shoot around the left side. Most people practice offhand shooting for this very reason. But would you really switch to your offhand when shit got real? I'm right handed, and I can't shoot for shit using my left hand. Not to mention that my sling would get all tangled up switching from right to left and back. The last thing I want to have to do is defend my life using my left hand! I think that most people, when it came down to it, would keep shooting using their dominant hand.
If you hold the rifle tilted 45 degrees, then as a right handed shooter you can shoot around the left side of cover, or sweep a room, much better than you can while holding the weapon vertical. If you haven't ever felt the difference, go grab your gun and see for yourself. But you can only shoot this way, at 45 degrees, if you have an optic lined up there. Surprisingly, I've found that holding the gun 45 degrees is also more comfortable on my wrist joints, and so why not hold it this way all the time, instead of just when shooting around left handed cover? If you make this your primary way of holding the rifle, then you never have to worry about left/right sided cover so much at all because you can do both.
Now once you've got something like a RMR at 45 degrees, you've got room on your primary rail for a magnified optic. Since you won't be using it for quick target engagement anyway, it does not need to be a heavy clunky LPVO...you can use a nice leightweight 2-7x or 3-9x under 10oz. You'll have better and faster target acquisition at 1x using your 45 RMR than you would using a LPVO at 1x, you'll have a faster transition from 1x to high-magnification by simply turning the gun, in comparison to flipping a throw lever which requires taking one of your hands off the gun, and you'll have better glass at high magnification than you would using the LPVO. To top it off, the weight of your RMR (1 oz), + mount (1 oz), + 10oz scope + 3.5 oz scope mount, you're still at 15 oz, which is significantly lighter than your LPVO + mount!
Give it a try, you won't be disappointed ;)