I'm not going to get into the .223 debate as Austrian, DocGKR, Kevin, Dev_L and several others have covered it well. But let me take a moment to debunk some horrible info I have been seeing in this thread regarding shotgun ammo.
Please, if you own a shotgun for home defense, don't use birdshot as defensive ammo! Some folks worry about over-penetrating and therefore use this, but birdshot loads also underpenetrate in soft tissue as well. Most birdshot will be lucky to penetrate deeper than 4" in flesh. The FBI minimum standard for penetration in flesh is 12". What good will it do to shoot an attacker with an ineffective load that will not rapidly incapacitate them? And birdshot loads have proven time and again that they can't be reliably counted upon to do so.
I feel there is a far greater danger of the bad guy getting me because my rounds were ineffective, then killing my family after I am down. I'll take my chances using a proven round....00 buckshot. Anything smaller will not reliably get the job done. In fact, many police agencies have had poor results with #4 buck...and this shot size is huge compared to birdshot. Now take this advice any way you choose but birdshot is not a good choice for home defense. Use shot placement and tactics to defeat the bad guy and keep your family out of the line of fire. Then use proper ammo to get the job done right.
And while I am on the topic of underpenetration, let me say the same thing about MagSafe and Glaser ammo. While these companies write these eye catching stories about how effective their ammo is, keep in mind that about the best these will do is penetrate 8" in soft tissue, some worse than this. And this bullet fragments so figure much of it doesn't even make it that far. Magsafe and Glaser is about like using a shotgun with birdshot...only with less pellets. Again, not ideal.
The FBI decided that 12" of penetration was necessary to reach the vital organs and CNS from certain angles. Most people don't square their chest up to you and give you a direct in shot. They crouch, they turn, they move....meaning your shot may have to come in from the side where an arm could rob you of several inches of penetration or more before the bullet ever enters the thoracic cavity. The FBI standard is a good one and resulted from the study of the Miami shootout in 1986 which was a dark day in FBI history. So in short, when you choose ammo, make sure it is capable of making the biggest wound channel as possible and penetrate deeply enough to reach the vitals from ANY angle! Otherwise, take your chances using a load with inferior terminal performance.
And just in case anyone is wondering, I will list some of the rounds that have been proven, both scientifically and on the street in actual shootings. The following rounds all robustly expand/fragment and penetrate to at least 12", even through clothing:
9mm
-Winchester Ranger 127 gr +P+ JHP
-Winchester Ranger 147 gr JHP
-Speer Gold Dot 124 gr +P JHP
-Remington Golden Saber 147 gr JHP
-Federal Tactical 124 gr JHP
-Federal Tactical 135 gr +P JHP
.40 S&W
-Winchester Ranger 180 gr JHP
-Winchester Ranger 165 gr JHP
-Speer Gold Dot 180 gr JHP
-Federal Tactical 180 gr JHP
-Remington Golden Saber 180 gr JHP
.45 ACP
-Winchester Ranger 230 gr JHP
-Winchester Ranger 230 gr +P JHP
-Federal Tactical 230 gr JHP
-Speer Gold Dot 230 gr JHP
.357 Sig
-Winchester Ranger 125 gr JHP
-Speer Gold Dot 125 gr JHP
.223
-Black Hills or Hornady 75 gr OTM
-Black Hills or Federal 77 gr OTM
-Black Hills or Federal 69 gr OTM
-Black Hills 68 gr OTM
-Winchester Supreme Power Point Plus 64 gr JSP
-Federal 55 and 62 gr Trophy Bonded Bear Claw
-Black Hills 60 gr SP
.308
-Hornady 155 gr TAP (with AMAX bullet)
-Federal 150 gr Nosler Ballistic Tip
-Winchester Supreme 150 gr Ballistic Silvertip
-Loads using the 165 gr Sierra Game King
7.62X39mm
-Winchester Super-X 123 gr Power-Point
.30 Carbine
-Remington 110 gr JSP
12 Gauge
-Most any 00 or 000 buckshot loads will provide necessary penetration. However some may pattern better than others. The Federal Tactical 00 Buckshot is often a favorite.
I hope this little list is helpful to someone. While not all inclusive, it does list most of the best rounds when it comes to defensive criteria against human attackers. It is based upon research conducted by knowledgeable folks such as DocGKR, our own Tatjana and Brouhaha, and several others, as well as my own observations. If more details are needed, I will be happy to provide them later but there is only so much room in one post.
Penetration against glass, car bodies and other barriers is another story but most of the bonded bullet rifle loads do well, particularly the Federal Trophy Bonded and Nosler Partition. In handguns, the Speer Gold Dot is hard to beat for this purpose. And with shotguns, the Brenneke slugs have a good reputation.
-Charging Handle