There is some truth to if you want billet, get billet. My Grendel had a billet upper and it shot fine with one of my forged lowers, but I got a billet lower (same manufacturer as the upper) because I wanted on to match up. Well, that and my forged that was being used was going for another carbine. In fact, my Grendel is Seekins just like you described wanting (the SPR 3 on mine is not a keymod though because they were not available when I got mine). The barrel is 20" Satern in the SPR profile. The rail is awesome and a good choice. Seekins makes some nice stuff.
As far as function, the billet lowers work as the forged lowers do. Mine has ambi functionality so there is a plus if needed. I am currently kicking around the idea of forged vs billet for another rifle build, so I understand your dilemna.