ANY Key lock can be picked, or forced with the right tools and training in a very short period of time.
Combination locks must be defeated by drilling, listening for tumblers, etc.
Why do you think banks use combination locks on their vault doors? If you lose your key to the lock on your safety deposit box, they just drill it out and put in a new one for you.
Some combination locks and handles are designed to break off preventing the safe from being forced open.
I would worry more about the guy with a 3 1/2" mini grinder and a thin metal cutting blade who will zip a hole in the side of almost any safe in just a few short minutes and haul all of your stuff out.
Just try one on some of the metal gauges advertised on safes and you will see why most gun safe losses are from holes, not locks.
B.