As a fellow lefty, I'd be happy to share what I have found.
Shooting Southpaw is only a disadvantage if you let yourself believe that. All guns were secretly made for lefties.
Handguns:
get an ambi slide release and mag release. OR rack the slide with a secure overhand grip when finished with reloads or malfunctions and stop worrying about the damn "hollywood button". The only positive use for it is clearing a double feed. You DO practice clearing double feeds don't you?
For the mag release, if it absolutely can mot be moved from being "right handed", use your trigger finger to hit it.
When practicing one handed, you can rack your slide by catching the ejection port on your holster, belt buckle, etc. Righties do jot have this option.
AR Platforms:
Hold the rifle as you would shoot it. Notice how your thumb comfortably reaches the forward assist? Notice how your trigger finger can hit the bolt catch? Notice how you can actually look into the chamber to see what is wrong when your gun goes *click* instead of *bang*?
Use your trigger finger to sweep the fire select from safe to fire or get an ambi one. Mag changes can be done just as fast as the righties do it if you PRACTICE!!
Shotguns:
So the safety on an 870 is kind of a bitch. Meh. We can still reach and manipulate everything else just the same and our reloads can be done MUCH faster. Why? Because it's easier for us to load the first shell into the chamber and rack the action forward.
I believe everything else I wanted to cover has already been hit on.