Amos' isn't in a bad part of town, it's just outside of Uptown. The closest hotels I believe are in Uptown.
Food? What do you like? 300 East is a good place... It's located at 300 East Blvd.
Lupies on Monroe Rd is good eats cheap...
I think they closed the penguin :-( some of the best burgers and onion rings in town.
Up in Noda there are a few good places but going the other way from amos'. I'd recommend caba fish taco..
Philosophers stone over by the hospital is good, bar and food up front, bar with bands in the back...
Ri-ras is a pseudo Irish pub in the Uptown area.
I eat in way too many restaurants while traveling for work, when I'm home I like to eat at home, but it's still hard to go wrong with price's chicken Shack..
Enjoy and like any city... Regardless of where you are, keep your wits about you
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