Jeez I wish I caught you earlier because I thought I was the only one working up a 125 load for the AR-10. Virtually no data out there.
Now, I chose to go with the accubond bullet as it will retain nearly all of it's weight. Assuming your in a hunting application. The NBT going at the speeds you'll achieve, as others have mentioned, will likely grenade. Initially I chose to work up the 125 for maximum MPB zero, but i've ditched that and chose to zero at 100 and stick with it for the flatter trajectory. MPB just isn't for me.
Powder burn will make a great deal of difference here. I ran quickloads for my 16" barrel and the top performers were H4895 with a 94%BR, TAC with a 90.75%BR and the best which i chose H322 with a 99.08%BR. That will vary based on barrel length. Varget is way too slow of a burn IMO, you're likely seeing well under 90% with the 18" barrel.
Here's where i'm at currently. Please note the case volume is EXTREMELY important with this load. If you were to put this in a Lake City case which has much less case volume you'd likely have problems. I've seen similar velocity with 41.2 of the same powder in a LC case, 3.2 grains difference!
Hornady 308 match case: 56.42 grains volume
44.4gr H322
2.790" COL
2,819 FPS from a 16" barrel. (QL predicts that 2,938 is max velocity for 16" barrel within sammi spec).
I've worked up to 2,920 FPS but the accuracy fell off much above 2,825.
I'm gettin 1/2" groups at 100 with this load
I tried TAC and was able to get 2,821 FPS with 47.1 in a Hornady Case, 16" barrel.
Let us know how it turns out.