For me, self defense is the most important application for a firearm.
What would I do as a reloader?
I'd start with a good quality 230 gr JHP bullet.
Pick a primer. I use Winchester.
Sort through your cases and pull a batch that are all the same length (+/- a few mils) or trim them to same length.
Pull your barrel and measure the chamber depth and a maximum OAL for the bullet you will use. Make sure you are headspacing on the case rim and not jamming the bullet into the lands.
Set your crimp die to give a solid crimp but make sure you are still headspacing on the case mouth after crimping.
I'd load 5 at each of several increasingly large powder charges.
Shoot over a chronograph.
Based on your data, find a load that delivers 750 fps to 800 fps. I think you will end up below 800 fps because of the shorter barrel (I wouldn't try to go to the MIL-SPEC 820 fps, I think you'll find it is too hot).
Load a bunch (50-100) of that recipe and test them at the range - feeding, extraction, ejection, muzzle velocity, accuracy.
Zero failures is allowed. Failures require diagnosis and remedial action. Then, a retest.
Consider a replacement spring (new and possibly stiffer) and a buffer. If you make any changes whatsoever, do them before testing or a retest is needed.
I've found these small 45's to be a bit finicky at first but are fine once you get them running (springs and load).
Do not limp wrist the firearm. It may not cycle properly.