ztug...
No flames intended here. Im just trying to save your life....
Now, please step away from the reloading press...
Your question is: Would pistol powder make a difference? Yes. It would. You'd loose a rifle, and eye and part of a hand...
The 5.56/.223 is a rifle. The 300 AAC takes the 5.56, necks it up, and either fired subsonic loads at reduced speeds or fires supersonics at full speed. The potential use of a sabot enables one to use sub caliber bullets, at higher than normal speeds (using full charges). A subsonic sabot load would have so much Derp, it would implode.
Using pistol powder as a substitute for rifle powder in a full rifle charge (ie> Sabot) would cause spontaneous disassembly of said rifle and likely cause injury or death. If this isn't apparent to you, please stop loading. You'll kill yourself.
The ONLY time pistol powder is used in a rifle case is in some VERY limited situations where one wants a truly low velocity plinker load. Sometimes some one will do something like a little unique in in a 30-06 with cast lead plinker bullets for truly subsonic loads.
Fro