My rifle shoots a different poi when there is pressure towards the end of the stock compared to it resting right in front of the trigger guard/magazine area.
I pushed the takedown pin back towards the receiver as hard as I could, but there was still some wiggle to the rifle.

There's about 18" of difference at 50 yards depending on how I hold the rifle.

Anyone ever heard of this? Any fixes?

Have you read the manual?

Have you adjusted the lock-up mechanism?

https://ruger-docs.s3.amazonaws.com/_manuals/1022.pdf

page 14

No. I just did though. Thanks, problem should be fixed.... Now I feel like a dumb ass.

After you've taken the slack out of the adjustment, unlock and rotate the forearm to the side and then give the adjuster a couple more clicks.
That will help it lock up good and solid. You shouldn't have to muscle it closed but it should start to feel some tension about 1/2 way as you're rotating it closed.

You've had good advice in the posts above. I just did a test of a friend's Takedown; he was complaining of a similar problem with POI change after each disassembly/reassembly cycle. Tightened up the locking nut and then shot 5-shot groups, reassembling the rifle after each shot. It then held to a 2 MOA group. Made some other observations in my blog article at www.1022Companion.wordpress.com.

Among them: even with the barrel locked up tight, using a loop sling drastically deflected POI.

I concur with BobN.
My experience has been that it's very accurate if using the open sights because they're both located on the barrel assembly. But the POI shift from a red dot or scope mounted on the receiver has been fairly disappointing; especially after breaking down and reassembly. The barrel just isn't repeatable in relation to the receiver, especially at distances over 50yds.

BUT...there is an optics solution!  Amega Ranges manufactures a scout mount for the takedown model.
Because it mounts on the barrel/forearm, there's no relationship to be lost with the receiver when disassembled/reassembled. I've got a red dot on mine, but a pistol scope or scout scope (long eye relief) would work, too. Here's the link.
http://www.amegaranges.com/product_pages/takedown_10-22.php

I can easily lay hits on a 6" steel plate at 100yds and with holdovers can hit targets out to 150. And NO change in zero!
That's really all I can ask out of this model at the moment. Future plans are to mount a scout scope to make it more "distance friendly" for my old eyes.

Man a really small scout mount for a red dot would be awesome.

Something like the Volquartsen dovetail mount might work? (Designed for the MK series pistols.)










 
 

I'm glad I stumbled across this thread. I need to check my adjustment too. I had about a 3' POI shift at 50yds putting my SWR Spectre on yesterday.