What is the intended use of the pack? (EDC, Backpacking, Travel, Work, etc.)
How important is internal organization versus the 2000 cu. in. capacity? In my experience many multi day packs over 2000+ cubic inches do not have very impressive internal organization but accommodate aftermarket organization well.
If you put a ton of miles on your packs or are rough on them I would highly recommend saving to increase your budget to $375 or $400 and grab a pack along the lines of the kifaru x-ray, hill people gear umlindi, goruck gr2, or similar bomb proof pack if you can swing it. These packs will last a lifetime easily. If these don't fit the bill or are too far outside the budget give us a little bit more info and someone on here with a stronger pack fetish then I will be able to point you in the right direction!