Ruger does make one 22lr that's easy to clean. I ran 800 rounds of bulk ammo through my Ruger SR22 in one day without any issues at all. It can be bought with a factory threaded barrel, has a fixed barrel and an aluminum slide with a steel insert for the slide lock. Mine will eat anything except American Eagle and is pretty accurate. I'm not sure about the options for mounting a red dot, but I know it can be done.
I also have the Smith M&P 22 compact. It is very similar to the SR22, but all of them come with a threaded barrel. I only have a couple hundred rounds through it, so I can't attest to its reliability yet. So far the only issues I have had are with American Eagle as well.
Maybe one of tose two would interest you. They are both on the smaller side, but tons of fun and feel great in the hand.