Range and home defense? For the latter, get security film on the windows and beef up the doors and jambs, add a solar powered perimeter alarm that chimes inside when someone crosses it at night. Home defense is about the property and house. What gun you use when that completely fails? Whatever you have. I have an AR pistol for that job, a rifle cartridge with 30 round mags.
I did just get a S&W 4566, tho. All stainless, .45ACP, night sights, good trigger, runs on the range well according to owners, has a rail for a light for home work. I'm thinking a green laser illuminator you can focus - for about a 18" spot out to 50 feet. Should be bright enough to ID and small enough to center on the center of mass. Why 50 feet? Front to back of my house, should cover it.
Don't bother to shop retail for it, you can get new competition versions but they are over $750. A used LEO trade in nets you one for under $500 on the auctions.
It's completely the opposite of another plastic gun in a small caliber. Ammo is pretty cheap, tho, comparatively, and abundant, too. If the Tanfoglio or CZ seems attractive - and I think they are - then take a look at S&W 4566's. If not, they and many other make nice 1911's which are what the S&W was designed to replace.