Ive been known to carry my .45 redhawk with wood grips in a kramer horsehide holster. It tucks it up pretty tight.

18 grains of 2400 under 250 grain xtps or hardcast swc. Thats my load of choice for my blackhawk and puma 92 trapper too. Deer death

I've loaded and shot both cartridges a bunch.  I have since paired down to mostly 44Mag.

Assuming you will not reload and if ammo cost is of no concern, and you absolutely need the most power and biggest heaviest bullet, the Super Redhawk in 454 will be your best bet. 45 Colt will then be your plinking "45 Special" load.

If ammo cost and availability is of concern, then go for the 44 Mag.

It all boils down to your individual priorities:

Max Power = SRH in 454
Cheaper more available ammo = SRH in 44Mag


Recoil is another topic.  I don't consider myself recoil adverse, but the Casull was a little much for my liking.  44Mag was a perfect all arounder for me and is enjoyable to shoot.

After encountering a Moose in Maine last year, I decided I needed a dedicated woods gun, better than my 357. In looking at 45lc or 44mag, I decided on 44 because of ammo availability. I'm set up to reload, but I still follow the maxim that any caliber I own for serious purposes needs to be easily available at a big box store or lgs.

I own both.  But my vote would be .44 mag.

Then .44 Magnum all the way.  

The commercial High pressure .45 Colt loads are completely outside SAAMI spec, and you really have no clue what you are buying, plus .44 Mag is far more common.