I have the Ruger Blackhawk .45acp/LC Convertible, at the time I wasn't really into SA cowboy guns, just wanted to get back in to large caliber revolvers but another S&W N frame was too pricey.
Having a revolver that shoots .45acp is cheap shooting, and with the Blackhawk no need to mess with moonclips. I'm also not seeing any difference in accuracy between .45acp & light cowboy .45LC loads @ 25 yards.
But I'm finding that I'm shooting more .45LC than I thought, it's a pricier round but even though it's supposed to be a lighter load than .44mag a good hot .45LC will get the job done. The HSM 'bear loads' get the job done, and I've no doubt a large frame Blackhawk could eat these all day with no issues.
I'm also surprised just how good out of the box that Ruger SA trigger is, my last 'big' S&W was an 80's production model 29, probably the best revolver trigger I've ever had after a few years of use, and none of the new S&Ws were as good. The Ruger was.