MK318 is hard to beat for the cost. It does everything pretty decent.
I personally like Gold Dot 75gr/150gr, or MK318/MK319. Depending on the rifle I'm shooting, obviously. Gold Dot is very accurate, will expand out past 400 yards, and is rather nasty when it hits things in my experience. I've seen both people and animals hit by it. It happens to be rather effective. Part of my theory on that is that it expands so RAPIDLY when it hits meat, and it has sharp-ish "petals" rather than a "smooth dome" like most JSP's. It also expands to a very large diameter. It's just a very effective round, all in all.
That said, MK frags nasty, and that back half WILL EXIT.
If you are hunting for meat, or live in a community, I strongly suggest Gold Dot. If neither of those apply...find out which one the gun likes.