I did a test on an ati/ chiappa m4-22 upper myself. I found that the upper was unreliable with remington gold, and, like you, found the barrel nut less than hand tight. Tightening it alleviated the problem...temporarily. After 2k rounds I experienced the bolt face and breech being out of square, and soon after that...self destruction of the bolt. Depending what generation bolt you get, you are more likely to experience catastrophic failure in the m4-22. This barrel also accumulates leading VERY quickly and attributes to a decline in accuracy.
After i decided to ditch the poly upper, i found that the barrel indexing pin was slightly too large for the forged upper!! I squeezed it in, and all my reliability problems have disappeared.
As far as i understand, the dpms 22 upper is not supported for replacement parts. With the lack of support for dpms and the chiappa being crap, my vote goes to building with quality parts, plain and simple.