Like LR, I have a very early version of the QCB, not hydra. Have not used their newest offerings. But, I still love mine. I run 22LR, 556, 6x45, 458 Socom and now a 300 BLK. The only "issue" I have found to date is the latching mechanism depends upon the thickness of the flage on the barrel extension for fit. My 22LR barrel has an extension flange that was machined into the barrel, not a real extension. As such, it was a tad thick, and needed just a bit of filing for fit. That was better than too thin, which would be a no go. I think I have at one time or another "plugged" half a dozen 556 barrels into it, and the only not so great fit is a Colt 16". It's right at the lower end of flang thickness, and just does fit, although it shoots the most left of all of my calibers.
I was concerned when I bought it that the locking mechanism might loosen up with time, but this has not happened at all. Return to zero is fantastic, even with a quick detaching scope with recorded dope. And also unlike LR, I have finally gone to the lap top case for carrying and transport. Once you get a few calibers and all the associated goodies, organization and weight becomes a factor
I now prefer the primary weapon with two calibers and optics and mags in one case, and the rest of my things in a secondary bag.
Craig