I have a laptop on a dock, with attached kb, mouse, external HD, and so on. I recently upgraded to Windows 10, and it keeps shutting off my keyboard and HD! The mouse stays activated, but the kb requires a key tap sometimes to "wake up", and the HD routinely shuts down after just a few seconds of inactivity.

I have googled the issue before, and used the power settings tab under device manager (USB generic hub...all of them actually) to change the default port management setting--to no avail. The changed setting remains changed after re-start, but the port behavior is still to shut off.

Has anyone else dealt with this issue? What can I do?

power manglement or properties of each USB port and set to not manage power...

Right, did that. Even kept the changes after re-start. Same port behavior.

Dell Latitude E6540

Win10Pro Build 10586

All devices plugged into an e-Port 2 (Dell) dock; this same exact setup as when I was running Win7.

Not entirely sure what you mean by the last question, butt kb and mouse are <2 years old and in good repair, never gave me these issues before. External HD has also lived for years on my desktop; and would stay powered on unless I physically set the rocker switch on the back.

That's really my main worry...I can't imagine cycling on/off this often is good for a spinning drive...

This setting? For the root hub?

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Yeah, figured after almost three weeks you weren't coming back to the thread.

Device Manager -> Universal Serial Bus Controllers -> USB Root Hub (each one, if more than one) -> Properties -> Power Management tab -> Uncheck "Allow the computer to turn off this device to save power"

Or alternately, the BIOS updates referenced above.

Sorry, been a busy few weeks. Thanks for keeping tabs just the same. These BIOS updates will come out on top in a quick google search?

I would search on the Support section of the Dell site.